|
PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
|
|
|
Effects of
Vaccinium arctostaphylos on lipolysis and adipogenesis
in diabetic rats
|
Ahmad Ghorbani1,
Mohammad
Soukhtanloo2,
Ziba Rajaei3 and Mousa-Al-Reza Hadjzadeh4* |
1Pharmacological Research Centre of Medicinal Plants,
School of Medicine, Mashhad University of Medical Sciences, Mashhad,
Iran;
2Department
of Clinical Biochemistry, School of Medicine, Mashhad
University of Medical Sciences, Mashhad, Iran;
3Department of Physiology, School of Medicine, Isfahan University of
Medical Sciences, Isfahan, Iran; 4Neurocognitive
Research
Center and Department of Physiology, School of
Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
|
|
Abstract |
Several
experimental and clinical studies support hypolipidemic effect of
Vaccinium arctostaphylos fruits in
diabetic subjects.
However,
no study has yet evaluated the possible direct action of this plant
on adipose tissue. Therefore, the present work was
performed to investigate the effects of hydroalcoholic extract of V.
arctostaphylos fruits on
adipogenesis
and lipolysis. Preadipocytes were isolated from
retroperitoneal
adipose tissue of diabetic rats and
differentiated to adipocyte in the presence of this extract. The effect of
V.
arctostaphylos
extract on lipolysis was evaluated with organ culture
method.
The extract had no significant effect on lipid
droplet accumulation as evaluated with Oil Red O staining. Incubation of
preadipocytes with the extract for 24 h did not change the cell
viability.
The
extract, even at high concentrations (up to 1000 µg/ml) had virtually no
significant effect on lipolysis. In conclusion, the present data
demonstrated that V. arctostaphylos fruit
has no
effects on fat tissue adipogenesis and lipolysis
in diabetic rats.
|
Keywords:
Adipogenesis;
Diabetes; Lipolysis;
Vaccinium arctostaphylos |
|
To cite this article:
Ghorbani A,
M
Soukhtanloo,
Z Rajaei and MAR Hadjzadeh, 2014.
Effects of
Vaccinium arctostaphylos on
Lipolysis and adipogenesis in diabetic rats.
Res.
Opin.
Anim. Vet. Sci., 4(8): 437-441. |
|
|