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Measurement of serum amyloid A and C-reactive protein in serum and
synovial fluids of dogs, following experimental osteoarthritis
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Behrooz Nikahval,
Mohammad Saeed Ahrari Khafi*, Parinaz Danesh Ardakani and
Saeed Nazifi |
Department of Clinical Studies, School of Veterinary Medicine, Shiraz
University, Shiraz, Iran
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Abstract |
Osteoarthritis is a progressive
and relatively irreversible condition of articular cartilage which
affects the whole joint region at the end. At the beginning, when the
injury is limited to the cartilage, it has no or very minimal signs.
Once detected, considerable parts of the cartilage have been lost which
will not be substituted. Early diagnosis of any cartilage damage is a
topic of great interest. Acute phase proteins (APPs) concentrations
increase at the beginning of any inflammatory condition or tissue
injuries. The present study was conducted to measure the effects of
experimental osteoarthritis on Serum Amyloid A (SAA) and C-Reactive
Protein (CRP) as two of the most important APPs. For this study four
mature, mixed breed dogs weighing about 18 kilograms were selected and
their left knees’ cranial cruciate ligaments were transected through a 4
mm parapatellar incision. Radiography and measurement of SAA and CRP in
both synovial fluid and serum samples were performed before surgery and
on days 14, 28, 90 and 180. Statistical analysis of the results showed
that there was significant increase in both SAA and CRP after surgery.
The data from both synovial and serum samples were more significant when
compared with radiography over time, suggesting that measurement of
these two parameters in either synovial fluid or serum is diagnostic and
better in early detection of OA.
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Keywords:
Osteoarthritis; knee; dog;
amyloid; C-reactive protein |
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To cite this article:
Nikahval B, MSA Khafi, PD Ardakani and S Nazifi, 2016.
Measurement of serum
amyloid A and C-reactive protein in serum and synovial fluids of dogs,
following experimental osteoarthritis.
Res.
Opin. Anim. Vet. Sci., 6(9): 272-276. |
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