E-ISSN 2223-0343

Measurement of serum amyloid A and C-reactive protein in serum and synovial fluids of dogs, following experimental osteoarthritis

Behrooz Nikahval, Mohammad Saeed Ahrari Khafi*, Parinaz Danesh Ardakani and Saeed Nazifi

Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

 
Abstract

Osteoarthritis is a progressive and relatively irreversible condition of articular cartilage which affects the whole joint region at the end. At the beginning, when the injury is limited to the cartilage, it has no or very minimal signs. Once detected, considerable parts of the cartilage have been lost which will not be substituted. Early diagnosis of any cartilage damage is a topic of great interest. Acute phase proteins (APPs) concentrations increase at the beginning of any inflammatory condition or tissue injuries. The present study was conducted to measure the effects of experimental osteoarthritis on Serum Amyloid A (SAA) and C-Reactive Protein (CRP) as two of the most important APPs. For this study four mature, mixed breed dogs weighing about 18 kilograms were selected and their left knees’ cranial cruciate ligaments were transected through a 4 mm parapatellar incision. Radiography and measurement of SAA and CRP in both synovial fluid and serum samples were performed before surgery and on days 14, 28, 90 and 180. Statistical analysis of the results showed that there was significant increase in both SAA and CRP after surgery. The data from both synovial and serum samples were more significant when compared with radiography over time, suggesting that measurement of these two parameters in either synovial fluid or serum is diagnostic and better in early detection of OA.

Keywords: Osteoarthritis; knee; dog; amyloid; C-reactive protein
 
To cite this article: Nikahval B, MSA Khafi, PD Ardakani and S Nazifi, 2016. Measurement of serum amyloid A and C-reactive protein in serum and synovial fluids of dogs, following experimental osteoarthritis. Res. Opin. Anim. Vet. Sci., 6(9): 272-276.
 

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