This study was conducted to evaluate the comparative effect of garlic cinnamon with virginiamycin on performance of broiler chicks. A total 320 one day broiler chicks with an average weight of 39±30 g were randomly divided into 4 treatments. Each treatment was further divided into 4 replicates. Chicks were fed a basal diet as control group, basal diet + 0.02% garlic powder (T₁), basal diet + 0.02% cinnamon powder (T₂) and basal diet + 0.02% virginiamycin powder (T₃). At the end of trial (42 days), two birds form each treatment were weighed and slaughtered. Data showed that FI decreased significantly in T1, T2 and T3 in comparison to control (P<0.05). Body weight gain and total body weight were also significantly higher in treated groups. Triglyceride and cholesterol level decreased significantly in T₁, T₂ and T₃ group. LDL level decreased significantly and HDL levels increased in all of the treated groups. Antibody titre increased significantly in treated diet compared to the control group. We concluded that the use of garlic and cinnamon at the present level enhanced body performance, cholesterol profile and antibody titre on broiler chicks almost equally to the use of antibiotics.