E-ISSN 2223-0343

Effects of hitchner b1 vaccine antibodies on organ distribution, persistence and shedding of velogenic Newcastle Disease Virus (kudu 113) in chickens

Emmanuel Chukwudi Okwor1, Didacus Chukwuemeka Eze1, George O.N Echeonwu2, John Okpabi Ibu3, Paul Chekwube Eze1 and John Osita Okoye1

1Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka; 2Virology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute, Vom, Plateau State, Nigeria, 3Department of Veterinary Pathology and Microbiology, Federal University of Agriculture, Makurdi, Nigeria

 
Abstract

Newcastle disease (ND) is endemic in Nigeria. Control is by vaccination and one of the commonly used vaccines against the disease is Hitchner B1 vaccine. Kudu 113 virus is a velogenic strain of Newcastle disease virus (NDV) that have been characterised. ND is very common among vaccinated flocks with rapid spread or transmission. This study evaluated the effects of Hichner B1 induced humoral antibody response on the Kudu 113 viral distribution, persistence and excretion from experimentally infected chickens. Four hundred chickens were procured at day old and randomly assigned into three groups: unvaccinated and unchallenged (G1), unvaccinated and challenged (G2) and vaccinated and challenged (G3). Vaccination was done on day 2 of age and batches of birds in G2 and G3 were taken at specified intervals for challenge. Virus distribution and persistence in organs and shedding in the faeces of the infected birds were assessed by isolation studies and quantitative haemagglutination assay. Vaccination did not prevent viral replication but significantly reduced the distribution and shedding of Kudu 113. Peak distribution and shedding was seen between days 4 and 7 post challenge (PC) and virus persisted in the faeces of infected birds for a maximum of 21 days.

Keywords: Hitchner B1; Kudu 113 virus; chickens; distribution; virus shedding
 
To cite this article: Okwor EC, DC Eze, GON Echeonwu, JO Ibu, PC Eze and JO Okoye, 2015. Effects of hitchner b1 vaccine antibodies on organ distribution, persistence and shedding of velogenic Newcastle Disease Virus (Kudu 113) in chickens. Res. Opin. Anim. Vet. Sci., 5(8): 335-341.
 
 
 

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