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Effects of Vaccinium arctostaphylos on lipolysis and adipogenesis in diabetic rats

Ahmad Ghorbani1, Mohammad Soukhtanloo2, Ziba Rajaei3 and Mousa-Al-Reza Hadjzadeh4*

1Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 3Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; 4Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

 
Abstract

Several experimental and clinical studies support hypolipidemic effect of Vaccinium arctostaphylos fruits in diabetic subjects. However, no study has yet evaluated the possible direct action of this plant on adipose tissue. Therefore, the present work was performed to investigate the effects of hydroalcoholic extract of V. arctostaphylos fruits on adipogenesis and lipolysis. Preadipocytes were isolated from retroperitoneal adipose tissue of diabetic rats and differentiated to adipocyte in the presence of this extract. The effect of V. arctostaphylos extract on lipolysis was evaluated with organ culture method. The extract had no significant effect on lipid droplet accumulation as evaluated with Oil Red O staining. Incubation of preadipocytes with the extract for 24 h did not change the cell viability. The extract, even at high concentrations (up to 1000 µg/ml) had virtually no significant effect on lipolysis. In conclusion, the present data demonstrated that V. arctostaphylos fruit has no effects on fat tissue adipogenesis and lipolysis in diabetic rats.

Keywords: Adipogenesis; Diabetes; Lipolysis; Vaccinium arctostaphylos
 
To cite this article: Ghorbani A, M Soukhtanloo, Z Rajaei and MAR Hadjzadeh, 2014. Effects of Vaccinium arctostaphylos on Lipolysis and adipogenesis in diabetic rats. Res. Opin. Anim. Vet. Sci., 4(8): 437-441.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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