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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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Phylogenetic analysis of foot-and-mouth-disease virus type a circulating
in Tanzania
during 2008-2013
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Raphael Sallu1,2, ChristopherKasanga2,
Mkama Mathias1,2, Mmeta Yongolo1, Peter Njau3,
Mark Rweyemamu2, Gerald Misinzo2, Nick Knowles4,
Donald King4 and Philemon Wambura2 |
1Tanzania Veterinary Laboratory Agency,
Dar-Es-Salaam, Tanzania; 2Southern African Centre for
Infectious Diseases Surveillance-Sokoine University of Agriculture,
Morogoro, Tanzania; 3Ministry of Livestock and Fisheries
Development, Dar-Es-Salaam, Tanzania; 4WRLFMD, Institute for
Animal Health, Pirbright, United Kingdom
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Abstract |
Foot-and-mouth disease
virus (FMDV) serotype A is endemic in Tanzania and is one of the serotype
that is a major hindrance to the development of the national livestock
industry. The serotype is widely spread in the whole country, causing a
significant number of sporadic outbreaks throughout the year.
The main objective of this study was to use genetic data to
determine the distribution of FMDV type Atopotype and the possible
sources of sporadic incursions. Complete VP1 sequences, obtained from 20
samples were collected between 2008 and 2013 from different
Foot-and-Mouth disease (FMD) outbreaks areas. The sequences generated
were compared with previous ones obtained from the public gene bank.
Phylogenetic analysis of VP1 nucleotide sequences demonstrated a close
relationship to recent FMDV isolates from African genotype I and II that
circulate within the East Africa.
However, the data showed that the viruses from Tanzania are genetically heterogeneous and both
genotypes variants are endogenous to Tanzania. Furthermore, the FMDV in Tanzania were
closely related to those from neighbouring countries indicating that
there is a strong epidemiological link between neighbouring countries in
the region.
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Keywords:
Serotype A;
Phylogenetic;
Tanzania; VP1 sequencing;
Foot-and-Mouth Virus |
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To cite this article:
Sallu R, C Kasanga, M Mathias, M Yongolo, P Njau, M Rweyemamu,
G Misinzo, N Knowles, D King and P Wambura, 2014.
Phylogenetic analysis
of foot-and-mouth-disease virus type a circulating in Tanzania during
2008-2013.
Res.
Opin. Anim. Vet. Sci., 4(8): 420-426. |
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