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Phylogenetic analysis of foot-and-mouth-disease virus type a circulating in Tanzania during 2008-2013

Raphael Sallu1,2, ChristopherKasanga2, Mkama Mathias1,2, Mmeta Yongolo1, Peter Njau3, Mark Rweyemamu2, Gerald Misinzo2, Nick Knowles4, Donald King4 and Philemon Wambura2

1Tanzania Veterinary Laboratory Agency, Dar-Es-Salaam, Tanzania; 2Southern African Centre for Infectious Diseases Surveillance-Sokoine University of Agriculture, Morogoro, Tanzania; 3Ministry of Livestock and Fisheries Development, Dar-Es-Salaam, Tanzania; 4WRLFMD, Institute for Animal Health, Pirbright, United Kingdom


Foot-and-mouth disease virus (FMDV) serotype A is endemic in Tanzania and is one of the serotype that is a major hindrance to the development of the national livestock industry. The serotype is widely spread in the whole country, causing a significant number of sporadic outbreaks throughout the year.  The main objective of this study was to use genetic data to determine the distribution of FMDV type Atopotype and the possible sources of sporadic incursions. Complete VP1 sequences, obtained from 20 samples were collected between 2008 and 2013 from different Foot-and-Mouth disease (FMD) outbreaks areas. The sequences generated were compared with previous ones obtained from the public gene bank. Phylogenetic analysis of VP1 nucleotide sequences demonstrated a close relationship to recent FMDV isolates from African genotype I and II that circulate within the East Africa. However, the data showed that the viruses from Tanzania are genetically heterogeneous and both genotypes variants are endogenous to Tanzania. Furthermore, the FMDV in Tanzania were closely related to those from neighbouring countries indicating that there is a strong epidemiological link between neighbouring countries in the region.

Keywords: Serotype A; Phylogenetic; Tanzania; VP1 sequencing; Foot-and-Mouth Virus
To cite this article: Sallu R, C Kasanga, M Mathias, M Yongolo, P Njau, M Rweyemamu, G Misinzo, N Knowles, D King and P Wambura, 2014. Phylogenetic analysis of foot-and-mouth-disease virus type a circulating in Tanzania during 2008-2013. Res. Opin. Anim. Vet. Sci., 4(8): 420-426.

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