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Evaluation of acute complication of Naja naja oxiana venom on some biochemical parameters in Dutch rabbit

Fetemeh Yaghoubi1, Abbas Zare Mirakabadi2 and Abdolhamid Angaji1*

1Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran; 2Department of poisonous animals of serum institute of Razi, Karaj, Iran

 
Abstract

The aim of this study was to evaluate the effect of Naja naja oxiana venom on some biochemical parameters of rabbits. The serum samples from seven rabbits were collected before venom injection (control) and then 120 µg/kg venom (Naja naja oxiana) was injected intramuscularly to the rabbits and their plasma at the times of 1, 3 and 24 h were collected. Electrocardiogram strips (ECG) were taken from their hearts before and after venom injection. The enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine Kinas-MB (CK-MB) and creatine phosphokinase (CPK) were determined. The result showed significant rise in the amounts of these enzymes and the irregular activity of heart after the venom injection at 1, 3 and 24 h. The results indicated that Naja naja oxiana venom causes time-dependent alternations in serum enzymes.

Keywords: Snake venom; heart activity; biochemical factors
 
To cite this article: Yaghoubi F, AZ Mirakabadi and A Angaji, 2014. Evaluation of acute complication of Naja naja oxiana venom on some biochemical parameters in Dutch rabbit. Res. Opin. Anim. Vet. Sci., 4(6): 332-335.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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