A field trial on efficacy of Salcochek against weaning diarrhoea of piglets was undertaken. Twenty five White Yorkshire piglets of one month age irrespective of sex were divided into five different groups. Twenty piglets were diarrhoeac and 5 were healthy. Group A-C was treatments, comprising diarrhoeac piglets only. Group A piglets were treated with Ciprofloxacin-Tinidazole tab at the rate of 10 mg/kg body weight for 3-5 days. Group B was treated with mixture of Salcochek at the rate of 0.5kg/tonne of feed and Ciprofloxacin-Tinidazole at the rate of 10mg/kg body weight for 3-5 days depending upon severity of condition. Group C piglets were treated with Salcochek at the level of 1kg/tonne of feed for 3-5 days depending upon severity of condition. Group D was positive control, comprising of untreated diarrhoeac piglets. Group E was retained as negative control, comprising healthy piglet without any history of diarrhoea. Body weight was highest in group B treated with combined therapy of Salcochek and followed by healthy control group E, Salcochek alone treated group C and lastly in Ciprofloxacin -Tinidazole treated group A. Diarrhoeac piglets from group D had subnormal body weight. Ciprofloxacin-Tinidazole treated diarrhoeac piglets recovered in 4 days, while in combined as well as Salcochek alone treated piglets recovered in three days. Mortality of 20 and 60% was recorded in Ciprofloxacin-Tinidazole treated and untreated diarrhoeac piglets respectively, while there was no mortality in Salcochek treated groups. It can be concluded that Salcochek is efficacious in treatment of diarrhoea in piglets.