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Hepatotoxicity induced by potassium dichromate in chickens
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Shengnan Wang1,
Yanhan Liu1,
Xiao Zhang2,
Wang Xu2,
Ziqiang Cheng2
and
Jianzhu Liu* |
College of Veterinary Medicine, Research Center for Animal Disease
Control Engineering Shandong Province, Shandong Agricultural University,
Tai`an 271018, China
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Abstract |
This study
evaluated
hepatotoxicity induced by
potassium dichromate
in chickens via drinking water.
Seventy-two Hyland Brown male chickens were
randomly divided into 4 groups (18 chickens each group): Control group,
low-dose (2%LD50) Cr(VI) group,
middle-dose (6%LD50) Cr(VI)
group, high-dose (10%LD50) Cr(VI)
group. Potassium dichromate was given orally via drinking water to the
chickens for 42 day. The control group was treated with the same volume
of distilled water.
Blood biochemical indexes
(ALT, AST, GGT),
antioxidant indicators
(SOD,
GSH
and
MDA)
in liver homogenates
and
pathologic changes in tissues were detected at 14, 28 and 42 day
respectively. The levels of serum biochemical
indexes (ALT, AST, GGT) increased significantly (P<0.05) in
Cr(VI)-treated groups. The activities of SOD and GSH decreased
significantly (P<0.05) in the Cr(VI)-treated groups while the content of
MDA increased significantly (P<0.05) in the Cr(VI)-treated groups
compared to control with the increasing dose and time. The cells
of the liver treated with Cr(VI) were severely dilated and the liver
appeared severe inflamed and necrotic. The results
indicated that Cr(VI) can lead to
hepatotoxicity
damage in chicken with time and dose-dependent relationship.
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Keywords:
Cr(VI);
hepatotoxicity;
blood biochemical;
antioxidant
indicators |
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To cite this article:
Wang S, Y Liu, X Zhang, W Xu, Z Cheng and J Liu,
2015.
Hepatotoxicity induced by potassium dichromate in chickens.
Res.
Opin. Anim. Vet. Sci., 5(5): 224-228. |
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