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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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Role of proteasome-ubiquitination degradation
pathway in animal cancer - an insight
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Supriya Shiwani, Sung Jin Lee and Naresh Kumar
Singh*
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Deptartment of Animal Biotechnology, College
of Animal Life Sciences, Kangwon
National
University,
Republic of Korea
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Abstract |
Most
intracellular proteins are degraded by the proteasome, a multicatalytic
enzyme complex containing a 20S catalytic core and two 19S regulatory
complexes.
The proteasome is responsible for the degradation of
intracellular proteins that are particularly involved in cell cycle
control and the regulation of apoptosis. Preclinical studies have in the
past used various forms of proteosome inhibitors such as chemical (Bortezomib),
natural resources (marine microbial metabolites,
green tea polyphenols, flavonoids etc.) and metal complexes. Such
proteosome inhibitors have been observed to
decrease proliferation, induce apoptosis, and enhance the activity of
chemotherapy and radiation, and reverses chemoresistance in a variety of
hematologic and solid malignancies. However, their clinical significance and relevance of
targeting the tumor survival-associated proteasome pathway for cancer
treatment, intervention and prevention needs to be discussed. We
therefore, reviewed here how the structure and function of the proteasome deals with various
forms of proteasome inhibitors
that counteract cancer propagation in animals.
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Keywords:
Proteasome, p53;
Ubiquitin; neoplasm; cancer |
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To cite this article:
Shiwani
S, SJ Lee and NK Singh, 2014.
Role of proteasome-ubiquitination degradation
pathway in animal cancer - An insight.
Res.
Opin. Anim. Vet. Sci., 4(5): 224-232. |
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