The aim of the study was to evaluate the antimicrobial resistance against Salmonella isolated from swine farms in Abia State, Nigeria. Salmonella isolates (n=400) were obtained from 260 faecal samples and 90 environmental samples. Of the faecal samples comprises 80 piglets, 80 growers and 80 finishers, isolates were classified into susceptible, intermediate or resistant based on NCCLS guideline. Two-third of the isolates (6.4%) were susceptible to all of the 10 antimicrobials in the antibiotic disc. No noticeable resistance was recorded for amoxicillin, ceftriaxone, cephalothin, ciprofloxacin and nalidixic acid. About 0.8% isolates were resistant to gentamycin. The frequencies of resistance were higher for tetracycline (36.49%), streptomycin (23.5%), ampicillin (9.8%) and kanamycin (14.8%). The absence of resistance to the fluoroquniolones and low resistance to amoxicillin, gentamycin are findings that would be of great importance to public and animal health. The level of common resistance observed for kanamycin, streptomycin, ampicillin and tetracycline indicates the need for a more effective use of these antimicrobials.