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Wound healing effect of
hydroethanolic extract of Ribwort
plantain leaves in rabbits
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Farahpour MR¹* and Heydari A² |
1Department of Clinical Sciences, Faculty of Veterinary
Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran; 2Student
of veterinary medicine, Islamic Azad University, Urmia Branch, Urmia,
Iran
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Abstract |
Ribwort plantain is popularly used in the folk
medicine as wound healing, anti-inflammatory and for the treatment of
diseases of the respiratory tract and muscular pains. In the present
study, a hydroethanolic leaf extract of
Ribwort plantain was evaluated for non-infected wound healing. Forty
White New Zealand rabbits were divided into four groups.
Full-thickness skin wounds were created on thoracolumabar region on each
side of the dorsal midline in each rabbit.
Groups A and B received a placebo containing 2 and 4% of
hydroethanolic leaf extract of
Ribwort plantain respectively, group C served as placebo (positive
control) and finally group D was kept as control (negative control)
receiving no application. The rate of wound size was measured at day 4,
8, 12 and 16 while histological structures were studied on days 3, 7, 14
and 20 after surgery. The wound contraction results show that
Ribwort plantain
hydroethanolic extract reduced wound size especially from day 6 onward.
Further, Ribwort plantain
hydroethanolic extract decreased poly morph nuclear cells, and increased
mononuclear cells, fibroblast cell migration and new vascular formation.
Thus, this study demonstrated that hydroethanolic extract of
Ribwort plantain at dose rate of 2% is effective in stimulating the
closure of non-infected wounds.
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Keywords:
Ribwort plantain; wound healing; hydroethanolic extract; ointment;
rabbit |
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To cite this article:
Farahpour MR and A Heydari,
2015.
Wound healing effect of
hydroethanolic extract of Ribwort
plantain leaves in rabbits.
Res.
Opin.
Anim. Vet. Sci., 5(3): 143-147. |
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