E-ISSN 2223-0343

Wound healing effect of hydroethanolic extract of Ribwort plantain leaves in rabbits

Farahpour MR¹* and Heydari A²

1Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran; 2Student of veterinary medicine, Islamic Azad University, Urmia Branch, Urmia, Iran


Ribwort plantain is popularly used in the folk medicine as wound healing, anti-inflammatory and for the treatment of diseases of the respiratory tract and muscular pains. In the present study, a hydroethanolic leaf extract of Ribwort plantain was evaluated for non-infected wound healing. Forty White New Zealand rabbits were divided into four groups. Full-thickness skin wounds were created on thoracolumabar region on each side of the dorsal midline in each rabbit. Groups A and B received a placebo containing 2 and 4% of hydroethanolic leaf extract of Ribwort plantain respectively, group C served as placebo (positive control) and finally group D was kept as control (negative control) receiving no application. The rate of wound size was measured at day 4, 8, 12 and 16 while histological structures were studied on days 3, 7, 14 and 20 after surgery. The wound contraction results show that Ribwort plantain hydroethanolic extract reduced wound size especially from day 6 onward. Further, Ribwort plantain hydroethanolic extract decreased poly morph nuclear cells, and increased mononuclear cells, fibroblast cell migration and new vascular formation. Thus, this study demonstrated that hydroethanolic extract of Ribwort plantain at dose rate of 2% is effective in stimulating the closure of non-infected wounds.

Keywords: Ribwort plantain; wound healing; hydroethanolic extract; ointment; rabbit
To cite this article: Farahpour MR and A Heydari, 2015. Wound healing effect of hydroethanolic extract of Ribwort plantain leaves in rabbits. Res. Opin. Anim. Vet. Sci., 5(3): 143-147.

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