The objective of this study is to compare the anti-inflammatory effect of Ketoprofen drug and Hedera helix leaf extract on clinical and biochemical parameters in pneumonic calves. In this regard, a total number of 30 Holstein calves from 1 to 4 months, diagnosed with pneumonia, were identified and randomly assigned to the two groups, i.e., treatment groups 1 and treatment group 2, each containing had 15 calves. The calves of the treatment group 1 and 2 were treated with lincospectin antibiotics for 5 days. In one group, we used Hedera helix leaf extract and in the other group, we used Ketoprofen as anti-inflammatory medicine. Clinical symptoms were monitored on days 0 and 4 and blood biochemistry was examined. Regarding the clinical symptoms, both drugs showed the significant reduction in temperature, respiratory rate, and nasal discharge at the end of the study compared with the starting day. Ketoprofen and Hedera helix leaf extract were effective in reducing rectal temperature,mucosal hyperactivity, coughing after stimulation and hoarse respiratory sounds. On the other hand, Ketoprofen had a greater effect than the Hedera helix leaf extract (P<0.05). Concentration of albumin, fibrinogen and total protein were significantly decreased after the use of Hedera helix leaf extract and Ketoprofen (P<0.05). This decrease was higher in the Ketoprofen group (P≤0.05). Hedera helix leaves extract had good effects on reducing symptoms of calves pneumonia and could be used as a antiinflammatory drug in calf pneumonia.