E-ISSN 2223-0343

Clinical, behavioral, hematological and serum biochemical effects of neostigmine in normal dairy cows following subcutaneous and intramuscular administration of single dose

Zuhair Bani Ismail1*, Amin Al-Zghoul1 and Iyad Al-Zoubi2

1Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; 2Private veterinarian and farm owner, Irbid 22110, Jordan

 
Abstract

The objectives of this study were to describe the clinical, behavioral, hematological and serum biochemical effects of neostigmine following subcutaneous and intramuscular administration to normal dairy cows. A total of 8 normal, non-pregnant dairy cows were used in 2 experiments with 1 week rest time between the experiments. In the first experiment, cows received a single injection of neostigmine (0.02mg/kg) subcutaneously. In the second experiment, cows received a single injection of neostigmine (0.02mg/kg) intramuscularly. Cows were closely monitored for any clinical or behavioral effects before (T0), and at T10, T20, T30 and T60 following drug administration. Whole blood was collected from all cows before (T0) and after drug administration at T30 and T60. In both experiments, there were a significant increase (P<0.05) in the frequency of rumen motility and a significant decrease in systolic blood pressure. Cows developed signs of mild sedation (score 1 out of 3) for the entire observation period in both experiments. The frequency of bowel movement was significantly increased (P<0.05) with the passage of large volume of semi-liquid fecal material. Although, there was no atxia or recumbency, all cows exhibited mild signs of abdominal pain. There were no significant changes in any of the other clinical, hematology or serum biochemistry parameters. In conclusion, both subcutaneous and intramuscular administration of a single injection of neostigmine at a dose rate of 0.02mg/kg resulted in increased rumen motility and frequency of bowel movement in normal dairy cows.

Keywords: gastro-intestinal dysfunction; ruminants; bowel movement; prokinetic drugs
 
To cite this article: Ismail ZB, A Al-Zghoul and I Al-Zoubi, 2017. Clinical, behavioral, hematological and serum biochemical effects of neostigmine in normal dairy cows following subcutaneous and intramuscular administration of single dose. Res. Opin. Anim. Vet. Sci., 7(2): 49-53.
 
 
 
 

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