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Clinical, behavioral, hematological and serum biochemical effects of
neostigmine in normal dairy cows following subcutaneous and
intramuscular administration of single dose
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Zuhair Bani Ismail1*, Amin Al-Zghoul1 and Iyad
Al-Zoubi2 |
1Department
of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan
University of Science and Technology, Irbid 22110, Jordan; 2Private
veterinarian and farm owner, Irbid 22110, Jordan
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Abstract |
The objectives of this study were to describe the clinical, behavioral,
hematological and serum biochemical effects of neostigmine following
subcutaneous and intramuscular administration to normal dairy cows. A
total of 8 normal, non-pregnant dairy cows were used in 2 experiments
with 1 week rest time between the experiments. In the first experiment,
cows received a single injection of neostigmine (0.02mg/kg)
subcutaneously. In the second experiment, cows received a single
injection of neostigmine (0.02mg/kg) intramuscularly. Cows were closely
monitored for any clinical or behavioral effects before (T0), and at
T10, T20, T30 and T60 following drug administration. Whole blood was
collected from all cows before (T0) and after drug administration at T30
and T60. In both experiments, there were a significant increase (P<0.05)
in the frequency of rumen motility and a significant decrease in
systolic blood pressure. Cows developed signs of mild sedation (score 1
out of 3) for the entire observation period in both experiments. The
frequency of bowel movement was significantly increased (P<0.05) with
the passage of large volume of semi-liquid fecal material. Although,
there was no atxia or recumbency, all cows exhibited mild signs of
abdominal pain. There were no significant changes in any of the other
clinical, hematology or serum biochemistry parameters. In conclusion,
both subcutaneous and intramuscular administration of a single injection
of neostigmine at a dose rate of 0.02mg/kg resulted in increased rumen
motility and frequency of bowel movement in normal dairy cows.
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Keywords:
gastro-intestinal dysfunction; ruminants; bowel movement; prokinetic
drugs |
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To cite this article:
Ismail ZB, A Al-Zghoul and I Al-Zoubi,
2017.
Clinical, behavioral, hematological and serum biochemical effects of
neostigmine in normal dairy cows following subcutaneous and
intramuscular administration of single dose.
Res.
Opin. Anim. Vet. Sci., 7(2): 49-53. |
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