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Ameliorative effects of Lipitor against hypercholesterolemia-induced
nephrotoxicity in rats and their breast-feeding young
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Abdelalim A. Gadallah1,2 |
1Zoology Department, Faculty of Science, Mansoura
University, Egypt
2Preparatory Year Deanship, Jazan University, Kingdom
of Saudi Arabia
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Abstract |
The aim
of this study was to find the ameliorative effect of Lipitor in
nephrotoxicity resulting from hypercholesterolemia in mothers and their
young. Eighty fertile male and virgin Wistar female rats were used in
the present study. After mating and confirmation of pregnancy, the rats
were arranged into four groups (10 per group) as follows: control; G1,
Lipitor-treated group (2 mg/kg body weight, orally administered every
other day from the 6th day of gestation until 14 and 21 days
postnatal); G2, experimental hypercholesterolemic and G3,
Hypercholesterolemic and Lipitor-treatment. At the end of treatments,
kidney and femoral epiphysis of both control and experimental mother
rats and their offspring at 7 and 14 days were processed for
histological study. The results revealed that mothers
exhibited tubulo-necrosis,
glomerulonephritis and periglomerular and tubular leukocytic
infiltration. Maternal nephrotoxicity was reflected in the renal picture
of breast-feeding young at 2 and 3 weeks. Also, examining femoral
epiphysis of breast-feeding rat maternal fed on a hypercholesterolemic
diet exhibited a comparative reduction of epiphysis and derangement of
cartilage column and widened of cartilage stromata. The increased damage
and degeneration of cartilage cells and comparative reduction of
epiphyseal cartilage may lead to softening of bone, decreased its growth
rate and increased incidence of fractures. Furthermore Lipitor-treatment
alone or in combination with hypercholesterolemia improved femoral
epiphysis and renal tissue to some extent and not equal to normal ones.
In conclusion, hypercholesterolemia altered renal morphology which might
have affected synthesis of essential elements of bone formation leading
to defective bone growth in their offspring. Lipitor-treatment improved
maternal renal structure which also resulted in improved bone growth of
their young.
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Keywords:
Amelioration, lepitor, nephrotoxicity,
hypercholesterolemia, mothers, youngs
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To cite this article:
Gadallah AA, 2016.
Ameliorative effects of Lipitor against
hypercholesterolemia-induced nephrotoxicity in rats and their
breast-feeding young.
Res.
Opin. Anim. Vet. Sci., 6(2): 53-58. |
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