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Histological and morphological characteristics of placenta in the rats administrated with Glycyrrhiza glabra extract

Ehsan Hosseini*1, Ali Louei Monfared1, Milad Moloudizargari2, Shahin Aghajanshakeri2, Sepideh Toloomoghaddam3, Sahar Rahmatigavari3, Seyed Sajjad Babaeimarzangou2, Peyman Sepehrnia2 and Maziar Koohirostamkolaei2

1Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran
2Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
3Faculty of Pharmacy, Islamic Azad University of Pharmaceutical Sciences, Tehran, Iran


There is growing interest in the use of herbs to aid in the maintenance of health. Licorice root (Glycyrrhiza) has been employed in traditional Iranian medicine to treat infectious diseases. To do the experiments, a total of 40 Male and 40 female Balb/C mice aged 9 to 10 weeks were purchased from Razi Institute (Karaj, Iran). For mating, one female was placed into cage of one male overnight (12 h). Day 0 gestation was determined by a sperm-positive vaginal smear following copulation. The pregnant mice (n = 32) were randomly allotted into four equal groups (n = 8) in which mice were exposed to different doses of Glycyrrhiza glabra (50,100 and 200 mg/kg/day). On the 17th day of pregnancy, all of the animals were euthanized by chloroform. In the G. glabra treated mice compared to control, trophoblastic giant cells were significantly decreased in the number. In addition, massive hyperemia was seen in the labyrinth interhemal membrane compartment of placenta in the G. glabra treated mice. Significant increase in the placental weight as well as in the placental index (the ration of placental to foetal weight) were found in the treated groups with G. glabra extract in comparison to the control mice. Also, the thickness of placenta and its diameter was not affected by G. glabra exposure. In addition, the weight of fetuses in treated mice was decreased significantly. The results showed that the effects of G. glabra on the placental tissue are not dose-dependent.

Keywords: Glycyrrhiza glabra, histology, rat
To cite this article: Hosseini E, AL Monfared, M Moloudizargari, S Aghajanshakeri, S Toloomoghaddam, S Rahmatigavari, S Babaeimarzangou, P Sepehrnia and M Koohirostamkolaei, 2013. Histological and morphological characteristics of placenta in the rats administrated with Glycyrrhiza glabra extract. Res. Opin. Anim. Vet. Sci., 3(2), 60-63.

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