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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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Histological and
morphological characteristics of placenta in the rats administrated with
Glycyrrhiza glabra extract |
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Ehsan Hosseini*1, Ali Louei Monfared1, Milad Moloudizargari2, Shahin Aghajanshakeri2, Sepideh
Toloomoghaddam3, Sahar Rahmatigavari3, Seyed Sajjad Babaeimarzangou2, Peyman Sepehrnia2 and Maziar Koohirostamkolaei2
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1Faculty of Para Veterinary Medicine, Ilam
University, Ilam, Iran
2Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University,
Urmia, Iran
3Faculty of Pharmacy, Islamic Azad
University of Pharmaceutical Sciences,
Tehran, Iran
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Abstract |
There is growing interest in
the use of herbs to aid in the maintenance of health. Licorice root (Glycyrrhiza)
has been employed in traditional Iranian medicine to treat infectious
diseases. To do the experiments, a total of 40 Male and 40 female Balb/C
mice aged 9 to 10 weeks were purchased from Razi Institute (Karaj, Iran).
For mating, one female was placed into cage of one male overnight (12
h). Day 0 gestation was determined by a sperm-positive vaginal smear
following copulation. The pregnant mice (n = 32) were randomly allotted
into four equal groups (n = 8) in which mice were exposed to different
doses of Glycyrrhiza glabra (50,100 and 200 mg/kg/day). On the
17th day of pregnancy, all of the animals were euthanized by chloroform.
In the G. glabra treated mice compared to control, trophoblastic
giant cells were significantly decreased in the number. In addition,
massive hyperemia was seen in the labyrinth interhemal membrane
compartment of placenta in the G. glabra treated mice.
Significant increase in the placental weight as well as in the placental
index (the ration of placental to foetal weight) were found in the
treated groups with G. glabra extract in comparison to the
control mice. Also, the thickness of placenta and its diameter was not
affected by G. glabra exposure. In addition, the weight of
fetuses in treated mice was decreased significantly. The results showed
that the effects of G. glabra on the placental tissue are not
dose-dependent.
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Keywords:
Glycyrrhiza glabra,
histology, rat |
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To cite this article:
Hosseini E, AL Monfared, M Moloudizargari, S Aghajanshakeri, S
Toloomoghaddam, S Rahmatigavari, S Babaeimarzangou, P Sepehrnia and M
Koohirostamkolaei, 2013.
Histological and morphological characteristics of
placenta in the rats administrated with Glycyrrhiza glabra
extract.
Res.
Opin. Anim. Vet. Sci.,
3(2), 60-63. |
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