Peste-des-petits-ruminants (PPR) is a major economic disease affecting the pastoral herders in Democratic Republic of the Congo, with outbreaks in South Kivu province having devastating effects on the Mwenga, Shabunda, Fizi and Kalehe zones livelihoods. However, there is limited available data on livestock diseases and economic analysis in South Kivu. This study has attempted to estimate the direct economic loses occasioned by outbreaks of PPR based on perceived loss of benefits experienced by the South Kivu small ruminants holders from 2011-2016. It therefore targeted only small ruminant’s farmers who are keeping both goats and sheep and have reported the PPR outbreaks in their farms. Secondary data, informal interviews and focused group discussions using participatory epidemiology methods were used for the analytical model. Results showed that the daily losses associated with morbidity due to PPR were estimated at US$30.2 for sheep and 37.1$ for goats per farmer and approximatively US$11 for sheep and US$121 for goats due to mortality rate associated with PPR suspicion per farmer. Mortality and morality rates due to PPR in South Kivu were estimated respectively 31 and 22% in sheep and 51 and 49% in goats. PPR has serious economic impacts on pastoral livelihoods in South Kivu especially when you consider its annual economic loss. This study strengthens the basis for developing a system for the economic assessment of livestock diseases.