A study was conducted to investigate the effect of summer and spring season on the calcium (Ca), phosphorus (P), magnesium (Mg) thyroid hormones (T3 and T4), glucose, albumin, total protein and creatinin status. Twenty healthy camels were selected from different herds during summer and spring, raised in semi-arid area and blood samples were collected. Serum was separated and analyzed for Ca, P, Mg, T3, T4 and other metabolites. Results showed a significantly (P<0.05) higher Ca, T3, T4 and glucose levels during spring season. A significantly (P<0.05) higher creatinine level in the blood serum of camels during summer was also noted. No significant change in P, Mg, albumen and total protein was noticed. Furthermore, T3 and T4 levels of the camels were significantly (P<0.05) lower during summer season when compared with spring. In conclusion, climatic changes may cause significant changes in some mineral concentration, thyroid hormones and other metabolites.