E-ISSN 2223-0343

Evaluation of effectiveness of pest des petits ruminants vaccine in Northern Tanzania

1Daniel Mdetele*, 2Subira Mwakabumbe, 3,4Misago Seth and 2,5Michael Madege

1Sokoine University of Agriculture, Faculty of Veterinary Medicine, P. O. Box 3015, Chuo Kikuu Morogoro, Tanzania; 2Zonal Veterinary Centre lake zone, P.O Box 127 Mwanza, Tanzania; 3The Nelson Mandela African Institution of Science and Technology, School of Life Sciences and Bioengineering, P. O Box 447, Arusha, Tanzania; 4National Institute for Medical Research (NIMR), Tanga Medical Research Centre, P.O Box 5004, Tanga, Tanzania; 5Zonal Veterinary Centre Northern zone P.O Box 1068 Arusha Tanzania


After the incursion of Peste des Petits ruminants (PPR) in Tanzania in 2008, Ministry of Livestock and Fisheries Development (MLDF) in collaboration with development partners started to control the disease by vaccination of sheep and goats through the Vaccination for Control of Neglected Animal Diseases in Africa (VACNADA) project. Vaccination was carried out in Northern and Lake Zones, where Tanzania borders Kenya, the known entry point for the disease in East Africa. A cross sectional epidemiological study was carried out in the Tarime district to evaluate the effectiveness of PPR control by vaccination implemented in Tanzania. A total of 360 serum samples, 180 pre-vaccination and 180 post-vaccination of sheep and goats were randomly retrieved from lake zone. Retrieved serum samples were serologically analyzed using a monoclonal antibody-based competitive enzyme-linked immunosorbent assay (c-ELISA) to assess the seroprevalence of PPR before and after vaccination. There was a statistically significant difference in seroconversion between pre- and post-vaccination samples. The pre-vaccination and post-vaccination seroprevalence of PPR in sheep and goats from nine representative villages were found to be 3.3% and 71.3% respectively (P<0.0001). Mean change in seroconversion rates across villages was found to be 67.8% (range 45 to 80%). Significantly higher acquisition of antibodies following vaccination suggests positive response that could be protective for sheep and goats against PPR. Efforts should be made to upscale vaccination coverage as well as carrying out further studies to evaluate the role of PPR vaccination in protection against this disease in small ruminants.

Keywords: PPR vaccine; effectiveness; competitive ELISA; Tanzania
To cite this article: Mdetele D, S Mwakabumbe, M Seth and M Madege, 2015. Evaluation of effectiveness of pest des petits ruminants vaccine in Northern Tanzania. Res. Opin. Anim. Vet. Sci., 5(10): 401-405.

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