E-ISSN 2223-0343

Effects of cigarette smoking on histology of trachea and lungs of albino rat

Shraideh Ziad1*, Al-Awaida Wajdy2 and Badran Darwish3

1Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman, Jordan; 2Department of Biology and Biotechnology, American University of Madaba, Madaba, Jordan; 3Department of Anatomy and Histology, Faculty of Medicine, The University of Jordan,  Amman, Jordan


This work was an attempt to reveal the effects of a Jordanian cigarette smoke on albino rat tissues at the cellular level. Two groups of male albino rats were exposed to the cigarette smoke for three months on a daily basis, using a special modified smoking machine. Exposure of albino rats for 3 months to cigarette smoke caused drastic histological changes in the tracheal epithelium including epithelial cells proliferation, disruption of its cilia, and presence of inclusion bodies. There was a marked thickening in the alveolar wall of lung alveoli, collapsed alveoli and blood extravasations. These changes indicate that nicotine induced changes similar to those of chronic irritation of tissue may decrease the efficiency of gaseous exchange in alveoli and predispose to neoplastic changes.

Keywords: Cigarette smoking; trachea; lungs; Albino rat
To cite this article: Ziad S, AA Wajdy and B Darwish, 2013. Effects of cigarette smoking on histology of trachea and lungs of albino rat. Res. Opin. Anim. Vet. Sci., 3(10), 356-362.

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