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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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The effect of date palm fruit (Phoenix
dactylifera L.) on 7, 12-dimethylbenz (α) anthracene (DMBA)-induced
mammary cancer in rats |
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Hiba F. Al-Sayyed1, Hamed R. Takruri 1* and Maha
S. Shomaf2
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1Department
of Nutrition and Food Technology, Faculty of Agriculture, 2Department
of Pathology and Microbiology and Forensic Medicine, Faculty of
Medicine, The University of Jordan, Amman, Jordan
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Abstract |
This research was performed to study the effect of date palm fruit (Phoenix dactylifera L.) on the
7,12-dimethylbenz (α) anthracene-induced mammary cancer in rats. The
effect of feeding the fruit at two maturity stages (“Rutab” and “Tamr”)
was compared to that of feeding raw soybean seeds and injection with two
drugs, preventive and curative against mammary cancer, i.e., tamoxifien
and 17-β-estradiol respectively. For comparison purposes, another group
of rats was injected with sesame oil. Eighty three female weanling
Sprague-Dawley rats were randomly distributed into the treatment groups.
Each group received one of the dietary or drug treatments. Another group
of rats that received neither drug nor special dietary treatment served
as a positive/carcinogen control group. Still another group was injected
with sesame oil, which is the carcinogen vehicle at the time of
injecting the carcinogen, to serve as a negative/carcinogen control
group. Three weeks after the carcinogen administration, animals were
palpated twice per week to record the appearance of any lesion. At the
end of the 26-week feeding period, all animals were killed. Palpable
lesions, mammary tissue, and associated lymph nodes were removed, fixed,
and prepared for histopathological examination. The diets that contained
the date palm fruit reduced significantly (P<0.05) the incidence rate of
mammary cancer, palpable tumour multiplicity, tumour size and weight
compared to the positive/DMBA control group. In conclusion, the date
palm fruit (Phoenix
dactylifera L.) protected against DMBA-induced mammary cancer in the
initiation, promotion, and progression stages of DMBA-induced mammary
carcinogenesis. The effect was comparable with that of the two drugs (tamoxifen
and 17-β-estradiol). Further research is required to elucidate the
possible mechanisms that might have contributed to the preventive effect
of this fruit against mammary cancer.
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Keywords:
Date palm fruit; "Rutab”; "Tamr”; 7, 12-dimethylebenza (α) anthracene;
mammary cancer |
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To cite this article:
Al-Sayyed HF, HR Takruri and MS Shomaf,
2014.
The effect of date palm fruit (Phoenix
dactylifera L.) on 7, 12-dimethylbenz (α) anthracene (DMBA)-induced
mammary cancer in rats.
Res.
Opin. Anim. Vet. Sci., 4(1), 11-18. |
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